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37 pictures and 121 papers on the plasmocyte: the pictures by method, the papers by section. A picture opens large on a click and goes to its paper on a second. Every PMID plasmo.site cites (281) is checked against PubMed for retractions at each build: none found.

Electron microscopy 7

Plasma cell ultrastructure and glycocalyx thickness in the jejunal mucosa of HC subjects and IBS-D patients. (A) Representative transmission electron microscopy images of plasma cells from HC (left panel) and IBS-D (right panel) groups. Inserts show the morphology of the RER in each group. Bar represents 1 µm. (B) Quantification of the percentage of RER area in the cytoplasm (%RER) in plasma cells in HC (n = 11) and IBS-D (n = 9) groups. (C) Correlation assessment between the %RER and the number of mitochondria per plasma cell (pooled participants, n = 20). (D) Representative transmission electron microscopy images of the glycocalyx overlying the microvilli from HC (left panel) and IBS-D (right panel) groups.

Pardo-Camacho, Ganda Mall, Martinez et al 2022, Cells · CC BY 4.0

Combined inhibition of p97 and the proteasome dramatically affects ER configuration. ( A ) RPMI 8226 myeloma cells were stained with ER Tracker Blue-White DPX following treatment for 24h with bortezomib (BTZ; 5nM), Eer1 (5µM), or both. Representative confocal microscopic images show minor ER alterations after BTZ treatment, transformation of tubule-lamellar into globular ER structures after treatment with Eer1, and widespread ER vacuolisation after dual treatment. ( B ) Representative electron microscopic images of OPM-2 cells after treatment with BTZ (5nM), Eer1 (5µM), or BTZ and Eer1, for 24h. Arrows indicate classical ER in control cells, black arrowheads indicate moderately dilated and disrupted ER in Eer1-treated cells, and open arrowheads indicate vacuolised ER with reduced ribosomes on the cytosolic ER surface. Another cell treated with Eer1 and BTZ is shown at lower magnification (right panel). Areas of dilated perinuclear space are indicated by asterisks. Nu, nucleus.

Auner, Moody, Ward et al 2013, PLoS ONE · CC BY, version not stated by the source

Ufbp1 is required for endoplasmic reticulum (ER) expansion in antibody-secreting cells. e Transmission electron microscope images of CD138 + cells sorted from LPS-stimulated B cell cultures from Ufbp1 F/F and Ufbp1 F/F CD19 cre mice. Scale bars are 1 µm. f Transmission electron microscope images of bone marrow plasma cells isolated from mice of indicated genotype. Scale bars are 1 µm.

Zhu, Bhatt, Sivaprakasam et al 2019, Nature Communications · CC BY 4.0

Detection of structures surrounded by four membranes in the "apicoplast-minus" parasites by immuno-EM. (A-C) ACP-positive structures surrounded by a single membrane (short black arrows). (D-F) ACP-positive structures surrounded by four membranes (long black arrows). (G) negative control with no primary antibody. Bars = 500 nm. Data are representative from two independent experiments.

Xu, Nwankwo, Prigge et al 2026, mSphere · CC BY 4.0

Detection of structures surrounded by four membranes in the "apicoplast-minus" parasites by immuno-EM. (A-C) ACP-positive structures surrounded by a single membrane (short black arrows). (D-F) ACP-positive structures surrounded by four membranes (long black arrows). (G) negative control with no primary antibody. Bars = 500 nm. Data are representative from two independent experiments.

Xu, Nwankwo, Prigge et al 2026, mSphere · CC BY 4.0

SLFN11-dependent suppression of rRNA synthesis by BTZ. A, Representative immunofluorescence images showing total SLFN11 (green, no preextraction) and DAPI (blue) in parental and SLFN11 KO KMS-34 cells. Scale bars, 10 um. B, SLFN11 immunoblots for whole-cell lysates from WT and SLFN11 KO clones of KMS-34 cells. C, Representative immunofluorescence images showing EU incorporation (green) and DAPI (blue). Top, KMS-34 cells. Bottom, KMS-27 cells. WT and SLFN11 KO clones were treated with BTZ (0.1 umol/L) for indicated time points. Scale bars, 5 um. D, Quantification of EU signal intensities in individual cells. Mean +/- SEM are shown. ****, P < 0.0001 (one-way ANOVA).

Arakawa, Taniyama, Suzuki et al 2026, Cancer Research Communications · CC BY 4.0

Normal morphological structure of Cd23-Cre Bhlha15 fl/fl plasma cells. (A) Electron microscopic analysis of bone marrow PCs of the indicated genotypes, which were sorted as B220int CD28+ CD138+ Lin- cells, fixed and processed as described in Methods. The scale bars indicate 2 um. The cells surrounding the PCs are erythrocytes. (B) Quantification of the content of endoplasmic reticulum (ER) in PCs of the different genotypes. The ER content was manually determined by using the Fiji software. Each dot represents one PC. In total, 33 Xbp1 fl/fl PCs, 14 Cd23-Cre Xbp1 fl/fl PCs, and 31 Cd23-Cre Bhlha15 fl/fl PCs were analyzed. (C) Staining of splenic PCs (TACI+ CD138+) of the indicated genotypes with Lyso-Tracker at day 7 after NP-KLH immunization (left). The MFI values of the Lyso-Tracker staining (right) are shown for all PCs analyzed in 3 independent experiments. Each dot represents one mouse. Statistical data (B, C) are shown as mean values with SEM and were analyzed with the unpaired Student's t test; * P < 0.05; **** P < 0.0001.

Wohner, Pinter, Bonelt et al 2022, Frontiers in Immunology · CC BY 4.0

Immunostaining and fluorescence 13

Double staining in the trephine biopsy, CD138 staining with Dako REAL Detection System Alkaline Phosphatase kit K5005, red chromogenic presentation, MDM2 staining with DAB chromogen in brown, x400. ( A ). Newly diagnosed MM trephine biopsy, positive nuclear staining (black arrow) and negative nuclear staining (red arrow). ( B ). Trephine biopsy after the therapy, positive nuclear staining (black arrow) and negative nuclear staining (red arrow).

Stanic Damic, Grubesic, Peric et al 2025, Medicina · CC BY 4.0

Syndecan-1 (CD138) expression in normal and coeliac mucosa using monoclonal MCA2459GA. A. Expression within normal intestine, showing syndecan-1 localises predominantly to the basolateral epithelial surface (original magnification x10). B. Higher power view (x40) of normal duodenum, showing similar epithelial localisation plus the presence of scattered syndecan-1+ plasma cells within the lamina propria. C,D. Low power view (x10) of 2 cases of coeliac disease, showing retention of epithelial staining similar to controls, plus additionally a dense confluent expression within the upper lamina propria. E,F. Higher power view (x40) of the subepithelial region in these cases. The lamina propria aggregates consist of cells with dense membrane staining (plasma cells), cells with recognisable nuclei and punctate cytoplasmic staining and scattered syndecan-1+ debris (shed ectodomains)

Salvestrini, Lucas, Lionetti et al 2014, PLoS ONE · CC BY 4.0

骨髓涂片胞质轻链免疫荧光结合FISH典型荧光信号（×100）A 1q21扩增（信号模式：3R2G）；B 1p32缺失（信号模式：2R1G）；C p53缺失（信号模式：1R1G）；D IGH易位（信号模式：1R1G1F）；E IgH/FGFR3融合基因（信号模式：1R1G2F）

Shi, Yang, Guo et al 2024, Chinese Journal of Hematology · CC BY 3.0

Multiplex immunofluorescence staining in sequential kidney biopsies. Using two multiplex immunofluorescence assays CD38-CD138-CD27 (A, C, E, G) and CD38-CD19-CD16 (B, D, F, H) revealed changing phenotypes of immune cells across consecutive biopsies. Representative images, including magnified regions of interest with separate detection channels were shown for 2nd (A, B), 3rd (C, D) and 4th (E, F) biopsies using a Zeiss LSM710 confocal laser scanning microscope (Zeiss, Oberkochen, Germany) with a 20x objective. From every section, 4-5 representative images per biopsy were subsequently analyzed for the frequency of immune cell subsets using QuPath software showing the mean cell counts per mm 2. White arrows indicate CD16+ cells (B). *in addition, CD38+ material colocalized with diffuse DAPI (4',6-diamidino-2-phenylindole) staining, indicating broken or lysed CD38+ cells.

de Fallois, Baatz, Kruger et al 2026, Frontiers in Immunology · CC BY 4.0

Expression of SLFN11, CD138, and Ki-67 in multiple myeloma (MM) patient samples and normal bone marrow. A, Representative dual immunohistochemical staining for CD138 (blue, membrane) and SLFN11 (brown, nuclear) in bone marrow samples from patients with MM. Patients 1 and 2 are primary (P; newly diagnosed), whereas patient 3 (R) represents a sample from a recurrent patient. 81%-98% CD138-positive myeloma cells express SLFN11. B, Dual immunohistochemical staining for CD138 (blue) and SLFN11 (brown) in normal bone marrow. Left, low magnification. Right, high magnification of the same field. Normal bone marrow contains 5.5%-6.8% plasma cells, of which 72%-85% demonstrate SLFN11 positivity, indicating that SLFN11 expression is an intrinsic feature of NPCs. Scale bars, 50 um (left) and 10 um (right). C, Representative dual immunohistochemical staining for CD138 (blue) and Ki-67 (brown, nuclear) to assess proliferative activity. Left and middle, patient 1 at primary diagnosis (P) and third relapse (R3), respectively. Right, normal bone marrow. The PCPI, defined as the percentage of CD138-positive cells coexpressing Ki-67, is markedly elevated in myeloma specimens compared with normal bone marrow, with further increases observed at relapse. Scale bars, 10 um. BM, bone marrow.

Arakawa, Taniyama, Suzuki et al 2026, Cancer Research Communications · CC BY 4.0

Expression of SLFN11, CD138, and Ki-67 in multiple myeloma (MM) patient samples and normal bone marrow. A, Representative dual immunohistochemical staining for CD138 (blue, membrane) and SLFN11 (brown, nuclear) in bone marrow samples from patients with MM. Patients 1 and 2 are primary (P; newly diagnosed), whereas patient 3 (R) represents a sample from a recurrent patient. 81%-98% CD138-positive myeloma cells express SLFN11. B, Dual immunohistochemical staining for CD138 (blue) and SLFN11 (brown) in normal bone marrow. Left, low magnification. Right, high magnification of the same field. Normal bone marrow contains 5.5%-6.8% plasma cells, of which 72%-85% demonstrate SLFN11 positivity, indicating that SLFN11 expression is an intrinsic feature of NPCs. Scale bars, 50 um (left) and 10 um (right). C, Representative dual immunohistochemical staining for CD138 (blue) and Ki-67 (brown, nuclear) to assess proliferative activity. Left and middle, patient 1 at primary diagnosis (P) and third relapse (R3), respectively. Right, normal bone marrow. The PCPI, defined as the percentage of CD138-positive cells coexpressing Ki-67, is markedly elevated in myeloma specimens compared with normal bone marrow, with further increases observed at relapse. Scale bars, 10 um. BM, bone marrow.

Arakawa, Taniyama, Suzuki et al 2026, Cancer Research Communications · CC BY 4.0

SEC24A&B-depleted secretory MM cells accumulate misfolded proteins and increase the size of the ER. a, b TPE-MI fluorescence was measured by flow cytometry after staining cells with 50 uM TPE-MI for 30 min. The data show the percentage change in median fluorescence intensity compared to the siRNA control condition for a AMO-1 and b NCI-H929 cells. Means +/-SEM are shown (n = 3-5 measurements). Statistical significance was measured with one-way ANOVA followed by Dunnett's test (*** P <0.001; * P < 0.05). Representative histograms are shown on the right side of each graph with the same color code. c After 32 h of siRNA-mediated transfection of MM cell lines, cells were treated with vehicle (DMSO), 2 uM KIRA6, or 40 uM STF083010 for an additional 16 h. Cell viability was then assessed using the CellTiter-Glo assay. Data represent the mean of three independent experiments +/-SEM. *** P < 0.001; * P <0.05, as calculated using a two-way ANOVA and Tukey post hoc test. d After 48 h of SEC24A&B co-knockdown, cells were stained with calnexin to label the ER, and confocal images of 3D reconstructions of the ER were acquired. Image stacks with 0.1 um steps along the z-axis were used to analyze ER morphology using ImageJ 3D-suite. ER volume was normalized to the corresponding cell volume. Quantification was performed from three independent experiments. Data are presented as violin plots. Dots represent individual cells, AMO-1 (blue) and NCI-H929 (pink), n > 50 for each condition. The right panel shows a representative set of images for each cell type. Scale bar, 10 um

Horzum, Oberacher, Haun et al 2026, Signal Transduction and Targeted Therapy · CC BY 4.0

Bone marrow biopsy H&E stain (x40 objective). Immunostaining was positive for CD138 (x40 objective), cyclin D1 (x40 objective), MUM1 (x20 objective), and negative for kappa and lambda staining (x40 objective).

Xu, Proctor 2026, EJHaem · CC BY 4.0

(A) Blood film (x100 objective) showed large atypical plasma cells, some with prominent nucleoli and plasmablast morphology; (B) bone marrow aspirate (x40 objective) showed background staining and heavy infiltration of plasma cells with atypical binucleated forms; (C) peripheral blood immunophenotyping showing a population (green colour) of cells that are CD45-CD5-CD19-CD20-CD56-CD33-CD23-Ig-.

Xu, Proctor 2026, EJHaem · CC BY 4.0

Expression of SLFN11, CD138, and Ki-67 in multiple myeloma (MM) patient samples and normal bone marrow. A, Representative dual immunohistochemical staining for CD138 (blue, membrane) and SLFN11 (brown, nuclear) in bone marrow samples from patients with MM. Patients 1 and 2 are primary (P; newly diagnosed), whereas patient 3 (R) represents a sample from a recurrent patient. 81%-98% CD138-positive myeloma cells express SLFN11. B, Dual immunohistochemical staining for CD138 (blue) and SLFN11 (brown) in normal bone marrow. Left, low magnification. Right, high magnification of the same field. Normal bone marrow contains 5.5%-6.8% plasma cells, of which 72%-85% demonstrate SLFN11 positivity, indicating that SLFN11 expression is an intrinsic feature of NPCs. Scale bars, 50 um (left) and 10 um (right). C, Representative dual immunohistochemical staining for CD138 (blue) and Ki-67 (brown, nuclear) to assess proliferative activity. Left and middle, patient 1 at primary diagnosis (P) and third relapse (R3), respectively. Right, normal bone marrow. The PCPI, defined as the percentage of CD138-positive cells coexpressing Ki-67, is markedly elevated in myeloma specimens compared with normal bone marrow, with further increases observed at relapse. Scale bars, 10 um. BM, bone marrow.

Arakawa, Taniyama, Suzuki et al 2026, Cancer Research Communications · CC BY 4.0

Expression of SLFN11, CD138, and Ki-67 in multiple myeloma (MM) patient samples and normal bone marrow. A, Representative dual immunohistochemical staining for CD138 (blue, membrane) and SLFN11 (brown, nuclear) in bone marrow samples from patients with MM. Patients 1 and 2 are primary (P; newly diagnosed), whereas patient 3 (R) represents a sample from a recurrent patient. 81%-98% CD138-positive myeloma cells express SLFN11. B, Dual immunohistochemical staining for CD138 (blue) and SLFN11 (brown) in normal bone marrow. Left, low magnification. Right, high magnification of the same field. Normal bone marrow contains 5.5%-6.8% plasma cells, of which 72%-85% demonstrate SLFN11 positivity, indicating that SLFN11 expression is an intrinsic feature of NPCs. Scale bars, 50 um (left) and 10 um (right). C, Representative dual immunohistochemical staining for CD138 (blue) and Ki-67 (brown, nuclear) to assess proliferative activity. Left and middle, patient 1 at primary diagnosis (P) and third relapse (R3), respectively. Right, normal bone marrow. The PCPI, defined as the percentage of CD138-positive cells coexpressing Ki-67, is markedly elevated in myeloma specimens compared with normal bone marrow, with further increases observed at relapse. Scale bars, 10 um. BM, bone marrow.

Arakawa, Taniyama, Suzuki et al 2026, Cancer Research Communications · CC BY 4.0

Expression of SLFN11, CD138, and Ki-67 in multiple myeloma (MM) patient samples and normal bone marrow. A, Representative dual immunohistochemical staining for CD138 (blue, membrane) and SLFN11 (brown, nuclear) in bone marrow samples from patients with MM. Patients 1 and 2 are primary (P; newly diagnosed), whereas patient 3 (R) represents a sample from a recurrent patient. 81%-98% CD138-positive myeloma cells express SLFN11. B, Dual immunohistochemical staining for CD138 (blue) and SLFN11 (brown) in normal bone marrow. Left, low magnification. Right, high magnification of the same field. Normal bone marrow contains 5.5%-6.8% plasma cells, of which 72%-85% demonstrate SLFN11 positivity, indicating that SLFN11 expression is an intrinsic feature of NPCs. Scale bars, 50 um (left) and 10 um (right). C, Representative dual immunohistochemical staining for CD138 (blue) and Ki-67 (brown, nuclear) to assess proliferative activity. Left and middle, patient 1 at primary diagnosis (P) and third relapse (R3), respectively. Right, normal bone marrow. Scale bars, 10 um. BM, bone marrow.

Arakawa, Taniyama, Suzuki et al 2026, Cancer Research Communications · CC BY 4.0

Expression of SLFN11, CD138, and Ki-67 in multiple myeloma (MM) patient samples and normal bone marrow. A, Representative dual immunohistochemical staining for CD138 (blue, membrane) and SLFN11 (brown, nuclear) in bone marrow samples from patients with MM. Patients 1 and 2 are primary (P; newly diagnosed), whereas patient 3 (R) represents a sample from a recurrent patient. 81%-98% CD138-positive myeloma cells express SLFN11. B, Dual immunohistochemical staining for CD138 (blue) and SLFN11 (brown) in normal bone marrow. Left, low magnification. Right, high magnification of the same field. Normal bone marrow contains 5.5%-6.8% plasma cells, of which 72%-85% demonstrate SLFN11 positivity, indicating that SLFN11 expression is an intrinsic feature of NPCs. Scale bars, 50 um (left) and 10 um (right). C, Representative dual immunohistochemical staining for CD138 (blue) and Ki-67 (brown, nuclear) to assess proliferative activity. Left and middle, patient 1 at primary diagnosis (P) and third relapse (R3), respectively. Right, normal bone marrow. The PCPI, defined as the percentage of CD138-positive cells coexpressing Ki-67, is markedly elevated in myeloma specimens compared with normal bone marrow, with further increases observed at relapse. Scale bars, 10 um. BM, bone marrow.

Arakawa, Taniyama, Suzuki et al 2026, Cancer Research Communications · CC BY 4.0

Stained sections and smears 13

Histopathology of Mott cells with Russell bodies (red arrows) compared to an almost normal plasma cell (white arrow, prominent nucleolus). Primary malignant myelomatous pleural effusion. H&E.

Mangla A, Agarwal N, Kim GJ, Catchatourian R. Clin Case Rep. 2016;4(8):803-6. DOI:10.1002/ccr3.634 · CC BY 4.0

Multinucleated plasma cell, H&E stain, extremely high magnification. An atypical form seen in some myeloma cases.

Nephron, Wikimedia Commons · CC BY-SA 3.0

A case of Multiple myeloma and the bone marrow smear shows plasma cells with eccentric nucleus, bluish cytoplasm and a pale Golgi zone. Nuclear details cannot be appreciated at this power. As for the glass slide, naked eye examination itself shows a blue staining. This is due to the romanowsky stain interacting with the fixed paraprotein on the blood/marrow film.

Dr. Roshan Nasimudeen · CC BY-SA 3.0

Examples of bone marrow samples colored by May-Grünwald-Giemsa, 1000× magnification. Plasma cell with morphologic immaturity: high nucleus/cytoplasm ratio and dispersed chromatin (A). Binucleated plasma cell and several plasma cells (PC) with dispersed chromatin (B). Bone marrow showing mature PC and a multinucleated plasma cell (C).

Pires, Barreto, Caetano et al. J Clin Med. 2025. Figure 5. · CC BY 4.0

Haematoxylin and eosin staining of a solitary plasmacytoma of the tibia showing sheets of malignant plasma cells infiltrating bone marrow. Figure 1 from Hu X et al.

Hu, Li, Hu et al 2026, Frontiers in Oncology · CC BY 4.0

Histopathologic features of plasma cell/plasmacytic idiopathic multicentric Castleman disease. (A) Hyperplastic follicles HE stain in 4x magnification; (B) prominent interfollicular plasmacytosis; HE stain in 10x magnification (inset: HE stain higher magnification- 40x); (C) presence of plasmacytoid immunoblasts 'white circles' HE in 40x magnification (inset: Immunostain CD30-positive immunoblasts in 40x magnification). HE, hematoxylin and eosin.

Alapat, Etebari, Van Rhee et al 2026, American Journal of Clinical Pathology · CC BY 4.0

IgA+ plasma cells in human duodenal lamina propria (healthy donor). Cryostat sections stained with anti-IgA (green). IgA+ plasma cells are visible in normal lamina propria; splenectomized patients show reduced IgA+ plasma cells in the same tissue.

Carsetti R, Di Sabatino A, Rosado MM et al. Front Immunol. 2020;10:2937. PMID: 31969880 · CC BY

Plasma cell showing eccentrically placed round nucleus with cartwheel chromatin pattern. Stain not specified; chromatin clumping is consistent with Wright or Giemsa.

Department of Pathology, Calicut Medical College, Wikimedia Commons · CC BY-SA 4.0

Multinucleated plasma cell, H&E stain, high magnification. An atypical morphological variant; normal plasma cells are mononuclear.

Nephron, Wikimedia Commons · CC BY-SA 3.0

Bone marrow aspirate smears of myeloma plasma cells stained with Wright-Giemsa, 1000x. Attention heatmap overlay (blue to red) shows cells driving a deep-learning subtype classifier. Four cytogenetic subtypes shown: t(4;14), t(11;14), del(17p), gain(1q).

Gao M, Yan M, Chen X et al. Front Oncol. 2026;16:1790130. PMID: 41930202 · CC BY 4.0

Loaded ASCs localize in the perivascular space of the BMOC. B cell subpopulations in human donor tissue are shown as percentages ( A ) and counts per 100,000 cells ( B ). ( C ) A schematic of lymphoid organoids displays the coculture of tonsil cells with CD40L and stromal cells in a PEG-4MAL synthetic hydrogel (top). Bottom: Representative ASC populations from day-0 tonsil samples and after 15 days of culture in the lymphoid organoids are illustrated. ( D ) Time-lapse microscopy captures loaded B cells (magenta) entering the central channel from the media channels and moving through the vessels (white), with a single cell tracked by a blue arrow. Scale bars, 500 um. ( E ) Loaded B cells (cyan) aggregate near the vessels (white), with the scale bar measuring 100 um. The zoomed areas highlight B cells outside (left) and inside (right) the vessels. ( F ) Representative Z-slices show B cell localization around niche markers: left: YZ view, top: XZ view, and center: XY view. Scale bars, 80 um. Yellow arrows highlight B cells that are located near pink CXCL12 or VCAM-1 staining. ( G ) Distance of ASCs from CXCL12 and VCAM-1 compared to randomized control distribution using Welch's unpaired t test.

Kramer, Dai, Corbin et al 2026, Science Advances · CC BY 4.0

Histopathology of the rib lesion shows dense sheets of plasma cells with eccentric nuclei, clumped chromatin, and a perinuclear hof, consistent with a monoclonal plasma cell infiltrate (H&E, original magnification x20).

Fang, Tian, Tang et al 2026, Frontiers in Medicine · CC BY 4.0

H&E staining of BM biopsy showing interstitial lymphocytic infiltrates. (A) 20x magnification. (B) 40x magnification.

Sternbach, Bishara, Gertz et al 2026, Case Reports in Hematology · CC BY 4.0

Light microscopy 1

IFI27 induces myeloma cell pyroptosis in a GSDME-dependent manner. (A, B) OCI-My5 and OPM2 cells were infected with increased IFI27 lentivirus as indicated, followed by pyroptosis morphology determination (A), and culture media were subjected to LDH measurement (B) (n = 3), after 72 h of overexpression of IFI27 with a concentration gradient. Scale bar, 20 um. (C) Myeloma cell lines were infected with IFI27 lentivirus for 72 h before cell lysates were prepared for IB assays against different GSDMs. (D-G) GSDME was stably knocked down from OCI-My5 and OPM2 cells by its specific sgRNA, followed by infection with IFI27 lentivirus. Seventy-two h later, cells were performed to phase-contrast microscopy analysis (D) and statistical analysis on pyroptotic cells (E); cell lysates were prepared for IB assays (F) and culture media were subjected to LDH release measurement (G) (n = 5). Scale bar, 20 um. (H-J) RPMI-8226 cells were infected with WT or D270A GSDME lentivirus alone or with IFI27 lentivirus for 72 h for IB assays (H), pyroptotic analysis on phase-contrast microscopy (I), and statistical analysis of pyroptosis rate of cells (J) (n = 6). Scale bar, 20 um. (K, L) Primary myeloma cells were infected with IFI27 lentivirus for 72 h followed by IB assays using cell lysates (K) and phase-contrast microscopy assays (L). Scale bar, 10 um. **, p < 0.01; ***, p < 0.001. EV, empty virus.

Cui, Sun, Liu et al 2026, Advanced Science · CC BY 4.0

Figures and diagrams 3

Normal plasma cells producing antibodies (top) versus excess myeloma plasma cells producing unneeded antibodies (bottom). Medical illustration, NCI 1995.

National Cancer Institute, National Institutes of Health. Image ID 2718. · public domain

Mature plasma cell: clock-face (cartwheel) nucleus, perinuclear hof (Golgi zone), and expanded basophilic cytoplasm packed with rough endoplasmic reticulum. Labeled illustration.

plasmo.site · CC0

B cell to plasma cell terminal differentiation: naive B cell, germinal center activation, plasmablast, and long-lived plasma cell. Key transcription factors IRF4, BLIMP1, and XBP1 labeled at each transition.

plasmo.site · CC0

Disorders 70

Filed by MeSH heading or keyword; each paper says which one matched. The Disorders page holds the dated feed.

  1. Hooda V, Goel H, Madan T, Sharma A. B-cell centrality dictates therapeutic efficacy across autoimmune diseases: a systematic review. Front Immunol. 2026;17:1906254. PMID: 42787283. keyword: rheumatoid arthritis
  2. Li X, Qiao Y. Transcriptomic associations and biomarkers in ANCA‑associated Glomerulonephritis and IgG4‑related Disease: A bioinformatics and machine learning study. PLoS One. 2026;21:e0358953. PMID: 42784621. MeSH: Immunoglobulin G4-Related Disease
  3. Deosthali S, Marti-Garcia B, Harris H, Werling N, Noad R, Gerner W, et al. Functional profiling of porcine precision-cut lymph node slices as an ex vivo model for TLR-mediated and PCV2-specific immune responses. Front Immunol. 2026;17:1927543. PMID: 42780644. MeSH: Circoviridae Infections
  4. Cui Y, Sun Y, Liu Z, Lai X, Zhao Y, Wang Y, et al. IFI27 and BAX are Essential for GSDME-Mediated Myeloma Cell Pyroptosis. Adv Sci (Weinh). 2026:e77164. PMID: 42669156. keyword: multiple myeloma
  5. Hincapie AM, Poirier A, Aubry I, Aumont P, Bhagrath A, Uetani N, et al. Ptpn2 limits plasma cell fate and antiviral immunity by integrating B cell receptor and IFN-γ signals in B cells. Sci Adv. 2026;12:eaec0162. PMID: 42616863. MeSH: Orthomyxoviridae Infections
  6. Cui X, Yu L, Zhang R, Huang Y, Hu Z, Li X, et al. Tea saponin-soybean oil submicron emulsion promotes durable protective immunity against Pasteurella multocida. Front Immunol. 2026;17:1899202. PMID: 42548716. MeSH: Pasteurella Infections
  7. Joshi MV, Hofland U, Morel L. Germinal center and extrafollicular dysregulation in systemic lupus erythematosus: Mechanisms and therapeutic opportunities. Autoimmun Rev. 2026;25:104146. PMID: 42503367. MeSH: Lupus Erythematosus, Systemic/etiology
  8. Shirai T, Kuzuya K, Kishi M, Ichikawa S, Sakakibara S, Nakai A, et al. Migration-dependent extrafollicular programming of preplasmablast age-associated B cells drives lupus pathogenesis. J Clin Invest. 2026;136:e204095. PMID: 42446945. MeSH: Lupus Erythematosus, Systemic/pathology
  9. Alturaiki W. BAFF as a Key Modulator of Respiratory Mucosal B Cell Immunity in Viral Infection and Mucosal Vaccination. Cells. 2026;15:1140. PMID: 42439617. keyword: respiratory viral infection
  10. de Mol J, Katra P, Smit V, Witteveen A, Tomas L, Andersson L, et al. Age-associated B cells predict coronary events in humans and aggravate murine atherosclerosis. Cardiovasc Res. 2026;122:1789-1802. PMID: 42433156. MeSH: B-Lymphocytes/pathology
  11. Arakawa Y, Taniyama D, Suzuki K, Yano S, Pommier Y. Schlafen 11 Is Overexpressed in Multiple Myeloma and Undergoes Nucleolar Translocation in Response to Bortezomib. Cancer Res Commun. 2026;6:1777-1793. PMID: 42424601. MeSH: Multiple Myeloma
  12. Horzum U, Oberacher H, Haun M, Geley S, Roman-Trufero M, Auner H, et al. Targeting endoplasmic reticulum export disrupts metabolic resilience in multiple myeloma. Signal Transduct Target Ther. 2026;11:262. PMID: 42409778. MeSH: Multiple Myeloma
  13. Tjønnfjord GE, Osnes LTN, Spetalen S, Haave U, Popperud TH, Maniaol AH, et al. Anti-MAG Polyneuropathy: Characterization of the Monoclonal Gammopathy and Clonal B-Cell Population. J Immunol Res. 2026;2026:e1959235. PMID: 42396941. MeSH: Polyneuropathies/etiology
  14. Praité A, Lambert JM, Ashi MO, Troadec E, Oblet C, Carle B, et al. Antibody-secreting Cells Integrate Efficient NMD With Non‑canonical UPR Signaling to Maintain Proteostasis and Support Massive Immunoglobulin Synthesis. J Mol Biol. 2026;438:169919. PMID: 42372940. MeSH: Multiple Myeloma
  15. Wang Y, Ji W, Teng F, Han Y, Xu H, Zhi Y, et al. Immunological profiling of rheumatoid factor-positive primary Sjögren's syndrome by single-cell RNA sequencing. Front Immunol. 2026;17:1822615. PMID: 42367820. MeSH: Sjogren's Syndrome
  16. Rødseth AV, Lundin KEA, Sollid LM, Iversen R. Celiac disease plasma cells recognize the active form of transglutaminase 2 with and without bound substrate. J Autoimmun. 2026;162:103591. PMID: 42314261. MeSH: Celiac Disease
  17. Chen C, Xiao G, Yang K, Han X, Yang Y, Zhou T, et al. MZB1 Modulates Inflammatory Severity in Severe Acute Pancreatitis through an IgA-Associated Intestinal Barrier Axis. Inflammation. 2026;49:178. PMID: 42283950. MeSH: Pancreatitis/pathology
  18. Sternbach N, Bishara S, Gertz MA, Vaxman I. Waldenström Macroglobulinemia Presenting With Hepatic Lesions: Case Report and Literature Review. Case Rep Hematol. 2026;2026:9908044. PMID: 42282257. keyword: extramedullary disease
  19. Porr C, Vidrighin A, Harris DM, Diaconu C. Correlations between IgG4-related disease, autoimmune pancreatitis, and allergic diseases. Front Immunol. 2026;17:1718303. PMID: 42238580. MeSH: Immunoglobulin G4-Related Disease
  20. Zachova K, Cutkova A, Kosztyu P, Ohyama Y, Takahashi K, Zadrazil J, et al. IgA nephropathy-associated breast milk B cell alterations. Front Immunol. 2026;17:1784598. PMID: 42183291. MeSH: Epstein-Barr Virus Infections
  21. Reinke JG, Schorr C, Lee KP. Why are long-lived plasma cells long-lived? Front Immunol. 2026;17:1785563. PMID: 42183219. keyword: multiple myeloma
  22. Maekawa R, Matsuoka R, Maeda Y, Fujimoto T. [A case of IgG4-related hypertrophic pachymeningitis and leptomeningitis presenting with cognitive impairment]. Rinsho Shinkeigaku. 2026;66:395-400. PMID: 42178244. MeSH: Meningitis/pathology
  23. Zhao W, Zhao Y, Li H, Yang B, Lu S, Fu X, et al. SSR4 Sustains Tertiary Lymphoid Structures by Regulation Quality Control of N-linked Glycosylation During B-cell Differentiation Into Plasmacyte in Colorectal Cancer. Adv Sci (Weinh). 2026;13:e75790. PMID: 42159884. MeSH: Colorectal Neoplasms
  24. Zhang N, Liu X, Zhu R, Dong WJ, Huang YH, Zhang YA, et al. Critical roles of CD4-1+ T cells and their secreted IL-21 in vaccine-induced humoral immunity in grass carp. Fish Shellfish Immunol. 2026;175:111421. PMID: 42119748. MeSH: Gram-Negative Bacterial Infections
  25. Cho SH, Jones MA, Meyer K, Anderson DM, Chetyrkin S, Calcutt MW, et al. B cell expression of an enzymatic intermediary in ether lipid biosynthesis promotes antibody responses and germinal center size. Elife. 2026;14:RP104580. PMID: 42044181. keyword: inflammation
  26. Wiggins KJ, Williams ME, Hicks SL, Padilla-Quirarte HO, Roman CJ, Akther J, et al. Transcriptional programming of early-forming memory B cells arises independently of cognate CD4+ T-cell interactions. J Immunol. 2026;215:vkag054. PMID: 42001515. MeSH: Orthomyxoviridae Infections
  27. Ji X, Qing P, Lyu H, Zhang S, Wu Y, Zhuang Y, et al. UPLC-MS/MS-based metabolomics analysis identifies disease-associated metabolic signatures of B cells from patients with IgG4-RD. Front Immunol. 2026;17:1777700. PMID: 41993164. MeSH: Immunoglobulin G4-Related Disease
  28. Zhang H, He W. Clinicopathological and Imaging Distinction Between Ocular Adnexal MALT Lymphoma and IgG4-Related Ophthalmic Disease. Am J Ophthalmol. 2026;288:92-104. PMID: 41985855. MeSH: Immunoglobulin G4-Related Disease
  29. Mai Z, Wei Y, Pan M, Fang G, Deng J, Huang Y, et al. B cell immune response to Talaromyces marneffei infection in HIV-negative patients and rat models. BMC Infect Dis. 2026;26:1006. PMID: 41965524. MeSH: Disease Models, Animal
  30. Barros da Silva P, Duarte A, Almadhi NH, Alazzaz R, Borges A, Cabeçadas J, et al. Exploring the intersection: adult orbital xanthogranulomatous disease and IgG4-related disease - report of 3 cases and literature review. Orbit. 2026;45:593-602. PMID: 41949590. MeSH: Immunoglobulin G4-Related Disease
  31. Gao M, Yan X, Chen L, Ouyang G, Liu Y, Chen S. Morphology-based cytogenetic risk prediction in multiple myeloma from bone marrow smears. Front Oncol. 2026;16:1790130. PMID: 41930202. keyword: multiple myeloma
  32. Wang L, Curry JL, Dai J, Wang DH, Strati P, Becnel MR, et al. A Rare Case of Cutaneous Crystal-Storing Histiocytosis With Kappa Light Chain Restriction and Unusual BCL6 Expression. J Cutan Pathol. 2026;53:682-686. PMID: 41913538. MeSH: Histiocytosis/pathology
  33. Wu Z, Wang C, Ma L, Xia D. Mesenchymal stem cells ameliorate Sjögren disease by suppressing B cells through the Pik3cb/Akt/mTOR pathway. Front Immunol. 2026;17:1761950. PMID: 41909663. MeSH: Sjogren's Syndrome
  34. Liao C, Chen Y, Ye C, Lin S, Bai L, Zhang Z, et al. The BAFF/APRIL system at the crossroads of B cell memory and autoimmune relapse: Implication into the therapeutic strategies. Autoimmun Rev. 2026;25:104042. PMID: 41903743. MeSH: Autoimmune Diseases/etiology
  35. Goto H, Sasaki Y, Abe Y, Yagi M, Mizumoto N, Onozato Y, et al. Endoscopically-detected small-intestinal lesions with dense infiltration of IgG4-positive plasma-cells. Clin J Gastroenterol. 2026;19:550-556. PMID: 41893956. MeSH: Plasma Cells/pathology
  36. Liu R, Ren T, Xu L, Wang N, Zhang Y, Yan H, et al. Single-cell atlas of B cell heterogeneity in lacrimal IgG4-related disorders: Unraveling the transition from inflammatory exhaustion to clonal malignancy. FEBS J. 2026;293:4992-5007. PMID: 41853890. MeSH: Lacrimal Apparatus/pathology
  37. Iborra-Pernichi M, de León P, Torres E, Defaus S, Blanco E, Andreu D, et al. Foot-and-mouth disease virus-derived dendrimer peptides induce germinal center-dependent antibody responses and IgG1 plasma cell differentiation in mice. Sci Rep. 2026;16:13198. PMID: 41813793. MeSH: Foot-and-Mouth Disease Virus
  38. Liu Y, Hu Y, Se-Rigeleng, Yang Z, Liu X, Yu J, et al. Nerandomilast attenuates idiopathic inflammatory myopathy-associated interstitial lung disease via inhibiting proliferation and differentiation of B cells. Front Immunol. 2026;17:1771007. PMID: 41789097. MeSH: Disease Models, Animal
  39. Alapat DV, Etebari P, Van Rhee F. Elucidating the grading intricacies of idiopathic multicentric Castleman disease histopathology: a pathologist's perspective. Am J Clin Pathol. 2026;165:aqaf134. PMID: 41774910. MeSH: Castleman Disease
  40. D'Souza LJ, Young JN, Coffman H, Petrow EP, Bhattacharya D. A genome-wide CRISPR screen reveals novel determinants of long-lived plasma cell secretory capacity. J Immunol. 2026;215:vkaf354. PMID: 41764730. MeSH: Multiple Myeloma
  41. Jiang G, Yan X, Zheng Y, Zhuang L, Liu C, Zhang J, et al. Modified Shenlingbaizhu decoction suppresses colon cancer via enhancing memory-like Tfh differentiation and B cell responses. Phytomedicine. 2026;153:158001. PMID: 41763139. MeSH: Colonic Neoplasms
  42. Mohammed SS, Alkhalifah AKS, Mirza R, Okinedo SO, Inampudi RA, Bibi A, et al. Follicular helper-like γδ T cells promote plasma cell differentiation in Behçet's disease. Front Immunol. 2026;17:1763174. PMID: 41737222. MeSH: Behcet Syndrome
  43. Raschdorf A, de Almeida LN, Solbach P, Kirstein MM, Marquardt JU, Schmelter F, et al. Colonic spatial single-cell proteomics and murine models link mitochondrial dysfunction to dimeric IgA-secreting plasma cell deficiency in Crohn's disease. Nat Commun. 2026;17:1590. PMID: 41680132. MeSH: Crohn Disease
  44. Duntas LH. The caprices of a trace element: selenium's considerable effects on Hashimoto's thyroiditis, though few on Graves' disease. Eur Thyroid J. 2026;15:ETJ260009. PMID: 41677203. MeSH: Graves Disease
  45. Sargen M, Sasaki A, Tiwari RK, Li XM. B cell development and longevity of IgE plasma cells. Allergol Int. 2026;75:380-387. PMID: 41672834. keyword: Allergic disease
  46. Hu X, Li D, Hu X, Li S, Wang P. Solitary plasmacytoma of the tibia: literature review and case report. Front Oncol. 2026;16:1503479. PMID: 41646436. keyword: plasma cell myeloma
  47. Li X, Zhang Y, Ji D, Li L, Deng Y, Wang H, et al. Multi-omics identifies an epithelial-B cell cross-talk that drives functional B cell diversion in breast cancer lymph node metastasis. Cell Signal. 2026;141:112394. PMID: 41610965. MeSH: B-Lymphocytes/pathology
  48. Grimsholm O, Zghaebi M, Hambrecht B, Kalic T, Udoye CC, Manz R, et al. Allergic Sensitization to Inhalant Allergens in the Upper Respiratory Tract-the B Cell Side. Allergy. 2026;81:1985-2000. PMID: 41578632. MeSH: Hypersensitivity/etiology
  49. Xu K, Proctor I. Non-Secretory Myeloma With Non-Producing Phenotype Presented as Plasma Cell Leukaemia With Plasmablast Morphology. EJHaem. 2026;7:e70224. PMID: 41568011. keyword: non‐secretary multiple myeloma
  50. Katayama H, Fahrmann JF, Olsen C, Irajizad E, Cai Y, Hsiao F, et al. Blood-Based Immunoglobulin-Bound Neoantigen Signatures Associated with MEN Type 1-Related Duodenopancreatic Neuroendocrine Tumor Progression. J Am Coll Surg. 2026;242:834-842. PMID: 41562477. MeSH: Neuroendocrine Tumors/pathology
  51. Tao P, Wang J, Fan P, Liu W, Lu W, Hu Y, et al. Enhanced formation of tertiary lymphoid structures shapes the anti-tumor microenvironment in gastrointestinal stromal tumors after imatinib targeted therapy. Theranostics. 2026;16:2829-2844. PMID: 41510151. MeSH: Gastrointestinal Stromal Tumors/pathology
  52. Ochiai K, Igarashi K. Feedback loops in B-cell chromatin regulation as a therapeutic target for modulating antibody production and malignancies: insights from BACH2. Exp Hematol. 2026;153:105284. PMID: 41489538. MeSH: B-Lymphocytes/pathology
  53. Tong G, Dai J, Liu Q, Gao X, Li S, Qiu HJ. Metabolic Reprogramming of Adaptive Immunity Induced by Viral Infections. Immunology. 2026;177:674-685. PMID: 41449719. keyword: viral infections
  54. Wang H, Chen S, Tang D, Chen M, Peng H, Zhang G, et al. IRF4 (MUM1) in B-cell malignancies: molecular mechanisms, biological functions, and clinical implications. Pathology. 2026;58:19-23. PMID: 41391979. MeSH: Multiple Myeloma
  55. Tokuyasu H, Matsuoka S, Arai K, Sakai H, Miwa K, Esumi C, et al. Nodular Pulmonary Sarcoidosis with a B-cell Reaction Similar to That of IgG4-related Disease. Intern Med. 2026;65:1948-1952. PMID: 41371647. MeSH: Immunoglobulin G4-Related Disease
  56. Merder AK, Moseman EA. Plasma cells in and around the central nervous system. Front Immunol. 2025;16:1735430. PMID: 41583430. keyword: CNS infection
  57. Wang L, Zhou L, Wang Z, ZhangBao J, Huang W, Tan H, et al. Dysregulated Tfh/B cells and their interactions in neuromyelitis optica spectrum disorder. Front Immunol. 2025;16:1704282. PMID: 41567208. keyword: neuromyelitis optica spectrum disorder
  58. Tieppo P, Shehade H, Martinoli C, Mercier M, Carbonez D, Rosewick N, et al. Inhibition of A2AR alleviates adenosine-mediated suppression of plasma cell differentiation. Front Immunol. 2025;16:1702402. PMID: 41472728. MeSH: Neoplasms
  59. Tang TF, Cheong CS, Looi CY, Wong WF, Gan GG. Mechanistic Insights and Advances of Bispecific T Cell Engaging Antibodies Therapy in Multiple Myeloma. Medicina (Kaunas). 2025;61:2113. PMID: 41470115. MeSH: Multiple Myeloma
  60. Ottens K, Satterthwaite AB. B-1 cells contribute to increased total IgM and shape IgG autoreactivity profiles in Lyn-/- mice but are not a major source of lupus-associated pathogenic autoantibodies. Front Immunol. 2025;16:1721021. PMID: 41445737. MeSH: Disease Models, Animal
  61. Quiroga R, Sanhueza S, Sepúlveda C, Antilef B, Muñoz C, Cabrera C, et al. CXCL9 and CXCL10 support the exacerbated humoral response in recovered COVID-19 patients who developed acute respiratory distress syndrome by promoting plasma cell differentiation, whereas CXCL9 also induces CD40L and CXCR3 upregulation on T helper cells. Front Immunol. 2025;16:1684704. PMID: 41425601. MeSH: Respiratory Distress Syndrome
  62. Lin W, Xie Y, Wang F, Wang S, Liu X, Hu F, et al. [Single-cell RNA sequencing of B cells reveals molecular typing in Sjögren syndrome]. Beijing Da Xue Xue Bao Yi Xue Ban. 2025;57:1032-1041. PMID: 41399063. MeSH: Sjogren's Syndrome
  63. Miao L, Zhou R, Zhang L, Feng L, Wang Y, Song P, et al. Unraveling the dual roles of tumor-infiltrating antibodies in solid tumors: friend or foe in the tumor microenvironment? Front Immunol. 2025;16:1671839. PMID: 41357192. MeSH: Neoplasms
  64. Stanić Damić M, Grubešić A, Perić Z, Jonjić N, Seili-Bekafigo I, Hauser G, et al. The Association and Significance of MDM2 and NF-κB Protein Expression in Multiple Myeloma. Medicina (Kaunas). 2025;61:1948. PMID: 41303785. MeSH: Multiple Myeloma
  65. Pires AM, Barreto JP, Caetano J, Soares MJ, Geraldes C, Fernandes B, et al. Multiple Myeloma Laboratory Diagnostics Made Simple: Practical Insights and Key Recommendations. J Clin Med. 2025;14:7115. PMID: 41096195. keyword: multiple myeloma
  66. Shi Y, Yang H, Guo R, Guo Z, Li JY, Wu YJ, et al. [Cytoplasmic light-chain immunofluorescence combined with FISH in bone marrow smears to detect cytogenetic abnormalities in multiple myeloma]. Zhonghua Xue Ye Xue Za Zhi. 2024;45:566-570. PMID: 39134488. MeSH: Multiple Myeloma
  67. Pardo-Camacho C, Ganda Mall JP, Martínez C, Pigrau M, Expósito E, Albert-Bayo M, et al. Mucosal Plasma Cell Activation and Proximity to Nerve Fibres Are Associated with Glycocalyx Reduction in Diarrhoea-Predominant Irritable Bowel Syndrome: Jejunal Barrier Alterations Underlying Clinical Manifestations. Cells. 2022;11:2046. PMID: 35805133. MeSH: Intestinal Mucosa/pathology
  68. Mangla A, Agarwal N, Kim GJ, Catchatourian R. Primary malignant myelomatous pleural effusion. Clin Case Rep. 2016;4:803-6. PMID: 27525090. keyword: multiple myeloma
  69. Salvestrini C, Lucas M, Lionetti P, Torrente F, James S, Phillips AD, et al. Matrix expansion and syncytial aggregation of syndecan-1+ cells underpin villous atrophy in coeliac disease. PLoS One. 2014;9:e106005. PMID: 25198673. MeSH: Celiac Disease
  70. Auner HW, Moody AM, Ward TH, Kraus M, Milan E, May P, et al. Combined inhibition of p97 and the proteasome causes lethal disruption of the secretory apparatus in multiple myeloma cells. PLoS One. 2013;8:e74415. PMID: 24069311. MeSH: Multiple Myeloma

Medications 28

Filed by MeSH heading or keyword; each paper says which one matched. The Medications page holds the dated feed.

  1. Hooda V, Goel H, Madan T, Sharma A. B-cell centrality dictates therapeutic efficacy across autoimmune diseases: a systematic review. Front Immunol. 2026;17:1906254. PMID: 42787283. MeSH: B-Lymphocytes/drug effects
  2. Deosthali S, Marti-Garcia B, Harris H, Werling N, Noad R, Gerner W, et al. Functional profiling of porcine precision-cut lymph node slices as an ex vivo model for TLR-mediated and PCV2-specific immune responses. Front Immunol. 2026;17:1927543. PMID: 42780644. MeSH: Toll-Like Receptor Agonists
  3. de Fallois J, Baatz S, Krüger BM, Dilz LM, Boldt A, Beck J, et al. Type-II-CD20-targeted therapy for CD38 antibody-refractory antibody-mediated rejection after kidney transplantation: a case report. Front Immunol. 2026;17:1867833. PMID: 42591348. MeSH: Graft Rejection/drug therapy
  4. Arakawa Y, Taniyama D, Suzuki K, Yano S, Pommier Y. Schlafen 11 Is Overexpressed in Multiple Myeloma and Undergoes Nucleolar Translocation in Response to Bortezomib. Cancer Res Commun. 2026;6:1777-1793. PMID: 42424601. MeSH: Multiple Myeloma/drug therapy
  5. Horzum U, Oberacher H, Haun M, Geley S, Roman-Trufero M, Auner H, et al. Targeting endoplasmic reticulum export disrupts metabolic resilience in multiple myeloma. Signal Transduct Target Ther. 2026;11:262. PMID: 42409778. MeSH: Multiple Myeloma/drug therapy
  6. Tjønnfjord GE, Osnes LTN, Spetalen S, Haave U, Popperud TH, Maniaol AH, et al. Anti-MAG Polyneuropathy: Characterization of the Monoclonal Gammopathy and Clonal B-Cell Population. J Immunol Res. 2026;2026:e1959235. PMID: 42396941. MeSH: Rituximab/therapeutic use
  7. Xu W, Nwankwo I, Prigge ST, Ke H. Inheritance of four-membrane-bound structures in the "apicoplast-minus" Plasmodium falciparum. mSphere. 2026;11:e0002426. PMID: 42370693. MeSH: Plasmodium falciparum/drug effects
  8. Chen M, Wang W, Cheng Y, Tang Y. Molecular characterisation of telitacicept response phenotypes in systemic lupus erythematosus: an exploratory integrated transcriptome and B-cell receptor repertoire profiling study. J Transl Med. 2026;24:1113. PMID: 42316250. MeSH: Lupus Erythematosus, Systemic/drug therapy
  9. Porr C, Vidrighin A, Harris DM, Diaconu C. Correlations between IgG4-related disease, autoimmune pancreatitis, and allergic diseases. Front Immunol. 2026;17:1718303. PMID: 42238580. MeSH: Immunoglobulin G4-Related Disease/drug therapy
  10. Maekawa R, Matsuoka R, Maeda Y, Fujimoto T. [A case of IgG4-related hypertrophic pachymeningitis and leptomeningitis presenting with cognitive impairment]. Rinsho Shinkeigaku. 2026;66:395-400. PMID: 42178244. MeSH: Meningitis/drug therapy
  11. Ugolkov Y, Volkova A, Helmlinger G, Peskov K, Sokolov V. Quantitative systems pharmacology model of B cell immune response in mouse. Front Immunol. 2026;17:1745710. PMID: 42148090. keyword: MIDD (model-informed drug development)
  12. Larue M, Bitoun S, Zuber J, Michel M, Talbot A. Bispecific T-cell engagers in autoimmune diseases: mechanisms of action, clinical evidence challenges, and therapeutic perspectives. Autoimmun Rev. 2026;25:104060. PMID: 42002248. MeSH: Antibodies, Bispecific/therapeutic use
  13. Barros da Silva P, Duarte A, Almadhi NH, Alazzaz R, Borges A, Cabeçadas J, et al. Exploring the intersection: adult orbital xanthogranulomatous disease and IgG4-related disease - report of 3 cases and literature review. Orbit. 2026;45:593-602. PMID: 41949590. MeSH: Immunoglobulin G4-Related Disease/drug therapy
  14. Padilla-Quirarte HO, Kania AK, Janto NV, Akdogan-Ozdilek B, Hicks SL, Roman CJ, et al. Heme enhances B-cell proliferation and plasma cell formation through reduced p21 and Rb expression. J Immunol. 2026;215:vkag025. PMID: 41847861. MeSH: Cell Proliferation/drug effects
  15. Liu Y, Hu Y, Se-Rigeleng, Yang Z, Liu X, Yu J, et al. Nerandomilast attenuates idiopathic inflammatory myopathy-associated interstitial lung disease via inhibiting proliferation and differentiation of B cells. Front Immunol. 2026;17:1771007. PMID: 41789097. MeSH: Cell Proliferation/drug effects
  16. Jiang G, Yan X, Zheng Y, Zhuang L, Liu C, Zhang J, et al. Modified Shenlingbaizhu decoction suppresses colon cancer via enhancing memory-like Tfh differentiation and B cell responses. Phytomedicine. 2026;153:158001. PMID: 41763139. MeSH: Drugs, Chinese Herbal/pharmacology
  17. St Clair LA, Watters EG, Yin A, Liu JA, Chaulagain S, Thompson EA, et al. Estradiol enhances influenza vaccine responses through B cell metabolic reprogramming in female mice. mBio. 2026;17:e0396525. PMID: 41744685. MeSH: B-Lymphocytes/drug effects
  18. Nakada T, Saito R, Ishigaki S, Takei H, Yoshimoto K, Akiyama M, et al. Integrating B Cell Differentiation Model With Real-World Data Informs Determinants for Antibody-Secreting Cell Depletions in Systemic Sclerosis. CPT Pharmacometrics Syst Pharmacol. 2026;15:e70221. PMID: 41731244. MeSH: Scleroderma, Systemic/drug therapy
  19. Duntas LH. The caprices of a trace element: selenium's considerable effects on Hashimoto's thyroiditis, though few on Graves' disease. Eur Thyroid J. 2026;15:ETJ260009. PMID: 41677203. MeSH: Selenium/therapeutic use
  20. Almohammad K, Young M, Vettorazzi S, Greulich F, Alkhatib M, Tuckermann J, et al. IgD-Expressing Mature B Cells Exhibit Enhanced Sensitivity to Glucocorticoid-Induced Cell Death. Eur J Immunol. 2026;56:e70137. PMID: 41581071. MeSH: Glucocorticoids/pharmacology
  21. Lu F, Wang S, Zhu M, Qu K, Zhu T, Wang H, et al. A decoy oligodeoxynucleotide favors the differentiation of CpG ODN-induced B cells into IL-10-producing Breg-like cells over plasma cells by restoring IRF4/IRF8 imbalance. Cell Mol Life Sci. 2026;83:76. PMID: 41571859. MeSH: Oligodeoxyribonucleotides/pharmacology
  22. Tao P, Wang J, Fan P, Liu W, Lu W, Hu Y, et al. Enhanced formation of tertiary lymphoid structures shapes the anti-tumor microenvironment in gastrointestinal stromal tumors after imatinib targeted therapy. Theranostics. 2026;16:2829-2844. PMID: 41510151. MeSH: Imatinib Mesylate/pharmacology
  23. Tong G, Dai J, Liu Q, Gao X, Li S, Qiu HJ. Metabolic Reprogramming of Adaptive Immunity Induced by Viral Infections. Immunology. 2026;177:674-685. PMID: 41449719. keyword: immunotherapy
  24. Tieppo P, Shehade H, Martinoli C, Mercier M, Carbonez D, Rosewick N, et al. Inhibition of A2AR alleviates adenosine-mediated suppression of plasma cell differentiation. Front Immunol. 2025;16:1702402. PMID: 41472728. MeSH: Adenosine/pharmacology
  25. Tang TF, Cheong CS, Looi CY, Wong WF, Gan GG. Mechanistic Insights and Advances of Bispecific T Cell Engaging Antibodies Therapy in Multiple Myeloma. Medicina (Kaunas). 2025;61:2113. PMID: 41470115. MeSH: Multiple Myeloma/drug therapy
  26. Zheng M, Chen J, Yang H. Engineered cell therapies for autoimmune diseases: evaluating CAR-T and CAR-M progress and prospects. Front Immunol. 2025;16:1658867. PMID: 41357209. MeSH: Immunotherapy, Adoptive
  27. Stanić Damić M, Grubešić A, Perić Z, Jonjić N, Seili-Bekafigo I, Hauser G, et al. The Association and Significance of MDM2 and NF-κB Protein Expression in Multiple Myeloma. Medicina (Kaunas). 2025;61:1948. PMID: 41303785. MeSH: Multiple Myeloma/drug therapy
  28. Auner HW, Moody AM, Ward TH, Kraus M, Milan E, May P, et al. Combined inhibition of p97 and the proteasome causes lethal disruption of the secretory apparatus in multiple myeloma cells. PLoS One. 2013;8:e74415. PMID: 24069311. MeSH: Adenosine Triphosphatases/antagonists & inhibitors

Signaling 36

Filed by MeSH heading or keyword; each paper says which one matched. The Signaling page holds the dated feed.

  1. Deosthali S, Marti-Garcia B, Harris H, Werling N, Noad R, Gerner W, et al. Functional profiling of porcine precision-cut lymph node slices as an ex vivo model for TLR-mediated and PCV2-specific immune responses. Front Immunol. 2026;17:1927543. PMID: 42780644. MeSH: Toll-Like Receptor Agonists
  2. Moës B, Mostafa A, Malempré R, Renson O, Piel G, Matagne A, et al. INPP5K limits PtdIns (4,5)P2 accumulation in CD19 microclusters and restrains CD19 co-receptor membrane proximity and BCR-proximal signaling in B cells. Front Immunol. 2026;17:1934292. PMID: 42755852. MeSH: Signal Transduction
  3. Kramer L, Dai Z, Corbin J, Ringquist R, Bhatia E, Petersen I, et al. Ex vivo bone marrow subniches influence the fate of human antibody-secreting cells. Sci Adv. 2026;12:eadz3976. PMID: 42726849. MeSH: Receptors, CXCR4
  4. Hincapie AM, Poirier A, Aubry I, Aumont P, Bhagrath A, Uetani N, et al. Ptpn2 limits plasma cell fate and antiviral immunity by integrating B cell receptor and IFN-γ signals in B cells. Sci Adv. 2026;12:eaec0162. PMID: 42616863. MeSH: Signal Transduction
  5. Hirakawa R, Hisamatsu M, Maekawa S, Asai E, Ohta M, Matsuo A, et al. Bursa of Fabricius-independent B cells establish an IgA-mediated intestinal barrier that safeguards gut-liver homeostasis. Proc Natl Acad Sci U S A. 2026;123:e2605569123. PMID: 42455659. MeSH: Receptors, CXCR4
  6. Seki N, Tsujimoto H, Tanemura S, Maeda Y, Kikuchi J, Kondo Y, et al. T peripheral helper 1 cells effectively drive atypical double-negative CD11chi B cells to antibody-secreting cells and play a pathogenic role in systemic lupus erythematosus. Clin Immunol. 2026;287:110749. PMID: 42447945. MeSH: Receptors, CXCR3
  7. Shirai T, Kuzuya K, Kishi M, Ichikawa S, Sakakibara S, Nakai A, et al. Migration-dependent extrafollicular programming of preplasmablast age-associated B cells drives lupus pathogenesis. J Clin Invest. 2026;136:e204095. PMID: 42446945. MeSH: Receptors, G-Protein-Coupled
  8. de Mol J, Katra P, Smit V, Witteveen A, Tomas L, Andersson L, et al. Age-associated B cells predict coronary events in humans and aggravate murine atherosclerosis. Cardiovasc Res. 2026;122:1789-1802. PMID: 42433156. MeSH: Receptors, LDL
  9. Praité A, Lambert JM, Ashi MO, Troadec E, Oblet C, Carle B, et al. Antibody-secreting Cells Integrate Efficient NMD With Non‑canonical UPR Signaling to Maintain Proteostasis and Support Massive Immunoglobulin Synthesis. J Mol Biol. 2026;438:169919. PMID: 42372940. MeSH: Signal Transduction
  10. Wang Y, Ji W, Teng F, Han Y, Xu H, Zhi Y, et al. Immunological profiling of rheumatoid factor-positive primary Sjögren's syndrome by single-cell RNA sequencing. Front Immunol. 2026;17:1822615. PMID: 42367820. MeSH: Receptors, Antigen, T-Cell
  11. Lu R, Swartwout BK, Oh JH, Biswas SR, van Pijkeren JP, Luo XM. Differences in the cell wall architecture drive strain-specific IgA induction by Limosilactobacillus reuteri. J Leukoc Biol. 2026;118:qiag088. PMID: 42345455. MeSH: Toll-Like Receptor 2
  12. Bach L, Chang Y, Arteaga Transito O, Ghasemi M, Steinheuer LM, Steffen T, et al. TGF-β and IL-2 differentially shape T follicular regulatory cell differentiation and stability in vitro. Cell Mol Immunol. 2026;23:1022-1037. PMID: 42342921. MeSH: Receptors, CXCR5
  13. Chen M, Wang W, Cheng Y, Tang Y. Molecular characterisation of telitacicept response phenotypes in systemic lupus erythematosus: an exploratory integrated transcriptome and B-cell receptor repertoire profiling study. J Transl Med. 2026;24:1113. PMID: 42316250. MeSH: Receptors, Antigen, B-Cell
  14. Ueno M, Kubo S, Todoroki Y, Nakayamada S, Tanaka Y. Immune regulation and cell metabolism in B cell subsets in patients with systemic lupus erythematosus. Front Immunol. 2026;17:1755589. PMID: 42273699. MeSH: Cytokines
  15. Xu Q, Shi L, Center for Human Immunology, Liu C, Kabat J, Behzadpour H, et al. SARS-CoV-2 infection and vaccination elicit distinct pharyngeal mucosal B cell responses in children. Nat Commun. 2026;17:6924. PMID: 42173827. MeSH: Receptors, CXCR3
  16. Luff DH, Vanes L, Boeing S, Tybulewicz VLJ. TACI regulates marginal zone B cell development. J Exp Med. 2026;223:e20251308. PMID: 42085021. MeSH: Signal Transduction
  17. Mai Z, Wei Y, Pan M, Fang G, Deng J, Huang Y, et al. B cell immune response to Talaromyces marneffei infection in HIV-negative patients and rat models. BMC Infect Dis. 2026;26:1006. PMID: 41965524. MeSH: Cytokines
  18. Wu Z, Wang C, Ma L, Xia D. Mesenchymal stem cells ameliorate Sjögren disease by suppressing B cells through the Pik3cb/Akt/mTOR pathway. Front Immunol. 2026;17:1761950. PMID: 41909663. MeSH: Signal Transduction
  19. Liao C, Chen Y, Ye C, Lin S, Bai L, Zhang Z, et al. The BAFF/APRIL system at the crossroads of B cell memory and autoimmune relapse: Implication into the therapeutic strategies. Autoimmun Rev. 2026;25:104042. PMID: 41903743. MeSH: Tumor Necrosis Factor Ligand Superfamily Member 13
  20. Liu Y, Hu Y, Se-Rigeleng, Yang Z, Liu X, Yu J, et al. Nerandomilast attenuates idiopathic inflammatory myopathy-associated interstitial lung disease via inhibiting proliferation and differentiation of B cells. Front Immunol. 2026;17:1771007. PMID: 41789097. MeSH: Signal Transduction
  21. St Clair LA, Watters EG, Yin A, Liu JA, Chaulagain S, Thompson EA, et al. Estradiol enhances influenza vaccine responses through B cell metabolic reprogramming in female mice. mBio. 2026;17:e0396525. PMID: 41744685. MeSH: Signal Transduction
  22. Mohammed SS, Alkhalifah AKS, Mirza R, Okinedo SO, Inampudi RA, Bibi A, et al. Follicular helper-like γδ T cells promote plasma cell differentiation in Behçet's disease. Front Immunol. 2026;17:1763174. PMID: 41737222. MeSH: Receptors, Antigen, T-Cell, gamma-delta
  23. Nechanitzky D, Smith LK, Nechanitzky R, Jafari SM, Haight J, Bontoux C, et al. Lymphocyte-derived cholinergic circuits modulate germinal center output and B cell activation. Nat Immunol. 2026;27:854-866. PMID: 41735533. MeSH: Signal Transduction
  24. Sargen M, Sasaki A, Tiwari RK, Li XM. B cell development and longevity of IgE plasma cells. Allergol Int. 2026;75:380-387. PMID: 41672834. MeSH: Signal Transduction
  25. Almohammad K, Young M, Vettorazzi S, Greulich F, Alkhatib M, Tuckermann J, et al. IgD-Expressing Mature B Cells Exhibit Enhanced Sensitivity to Glucocorticoid-Induced Cell Death. Eur J Immunol. 2026;56:e70137. PMID: 41581071. MeSH: Receptors, Glucocorticoid
  26. Lu F, Wang S, Zhu M, Qu K, Zhu T, Wang H, et al. A decoy oligodeoxynucleotide favors the differentiation of CpG ODN-induced B cells into IL-10-producing Breg-like cells over plasma cells by restoring IRF4/IRF8 imbalance. Cell Mol Life Sci. 2026;83:76. PMID: 41571859. MeSH: Toll-Like Receptor 9
  27. O'Callaghan E, Shields AM, Chang L, Umpierrez M, Newton D, Burns SO, et al. BAFF-R expression as a potential biomarker associated with COVID-19 vaccine non-responsiveness in antibody-deficient patients. Clin Exp Immunol. 2026;220:uxag004. PMID: 41559870. MeSH: B-Cell Activation Factor Receptor
  28. Tao P, Wang J, Fan P, Liu W, Lu W, Hu Y, et al. Enhanced formation of tertiary lymphoid structures shapes the anti-tumor microenvironment in gastrointestinal stromal tumors after imatinib targeted therapy. Theranostics. 2026;16:2829-2844. PMID: 41510151. MeSH: Chemokine CXCL12
  29. Wang L, Zhou L, Wang Z, ZhangBao J, Huang W, Tan H, et al. Dysregulated Tfh/B cells and their interactions in neuromyelitis optica spectrum disorder. Front Immunol. 2025;16:1704282. PMID: 41567208. MeSH: Cytokines
  30. Tieppo P, Shehade H, Martinoli C, Mercier M, Carbonez D, Rosewick N, et al. Inhibition of A2AR alleviates adenosine-mediated suppression of plasma cell differentiation. Front Immunol. 2025;16:1702402. PMID: 41472728. MeSH: Receptor, Adenosine A2A
  31. Tang TF, Cheong CS, Looi CY, Wong WF, Gan GG. Mechanistic Insights and Advances of Bispecific T Cell Engaging Antibodies Therapy in Multiple Myeloma. Medicina (Kaunas). 2025;61:2113. PMID: 41470115. keyword: cytokine release syndrome
  32. Quiroga R, Sanhueza S, Sepúlveda C, Antilef B, Muñoz C, Cabrera C, et al. CXCL9 and CXCL10 support the exacerbated humoral response in recovered COVID-19 patients who developed acute respiratory distress syndrome by promoting plasma cell differentiation, whereas CXCL9 also induces CD40L and CXCR3 upregulation on T helper cells. Front Immunol. 2025;16:1684704. PMID: 41425601. MeSH: Receptors, CXCR3
  33. Khunsri T, Tianpothong P, Kochayoo P, Thawornpan P, Suangtamai T, Leepiyasakulchai C, et al. Function of follicular helper 17 T cells in driving B cells for anti-DNA autoantibody production in patients with SLE. Lupus Sci Med. 2025;12:e001814. PMID: 41407436. MeSH: Cytokines
  34. Zheng M, Chen J, Yang H. Engineered cell therapies for autoimmune diseases: evaluating CAR-T and CAR-M progress and prospects. Front Immunol. 2025;16:1658867. PMID: 41357209. MeSH: Receptors, Chimeric Antigen
  35. Carsetti R, Di Sabatino A, Rosado MM, Cascioli S, Piano Mortari E, Milito C, et al. Lack of Gut Secretory Immunoglobulin A in Memory B-Cell Dysfunction-Associated Disorders: A Possible Gut-Spleen Axis. Front Immunol. 2019;10:2937. PMID: 31969880. MeSH: Toll-Like Receptor 9
  36. Auner HW, Moody AM, Ward TH, Kraus M, Milan E, May P, et al. Combined inhibition of p97 and the proteasome causes lethal disruption of the secretory apparatus in multiple myeloma cells. PLoS One. 2013;8:e74415. PMID: 24069311. MeSH: Signal Transduction

Publications 121

Filed by MeSH heading or keyword; each paper says which one matched. The Publications page holds the dated feed.

  1. Hooda V, Goel H, Madan T, Sharma A. B-cell centrality dictates therapeutic efficacy across autoimmune diseases: a systematic review. Front Immunol. 2026;17:1906254. PMID: 42787283. research paper
  2. Li X, Qiao Y. Transcriptomic associations and biomarkers in ANCA‑associated Glomerulonephritis and IgG4‑related Disease: A bioinformatics and machine learning study. PLoS One. 2026;21:e0358953. PMID: 42784621. research paper
  3. Deosthali S, Marti-Garcia B, Harris H, Werling N, Noad R, Gerner W, et al. Functional profiling of porcine precision-cut lymph node slices as an ex vivo model for TLR-mediated and PCV2-specific immune responses. Front Immunol. 2026;17:1927543. PMID: 42780644. research paper
  4. Moës B, Mostafa A, Malempré R, Renson O, Piel G, Matagne A, et al. INPP5K limits PtdIns (4,5)P2 accumulation in CD19 microclusters and restrains CD19 co-receptor membrane proximity and BCR-proximal signaling in B cells. Front Immunol. 2026;17:1934292. PMID: 42755852. research paper
  5. Kramer L, Dai Z, Corbin J, Ringquist R, Bhatia E, Petersen I, et al. Ex vivo bone marrow subniches influence the fate of human antibody-secreting cells. Sci Adv. 2026;12:eadz3976. PMID: 42726849. research paper
  6. Sprumont A, Bannard O. Germinal Center Selection and Plasma Cell Differentiation. Immunol Rev. 2026;342:e70169. PMID: 42669881. research paper
  7. Cui Y, Sun Y, Liu Z, Lai X, Zhao Y, Wang Y, et al. IFI27 and BAX are Essential for GSDME-Mediated Myeloma Cell Pyroptosis. Adv Sci (Weinh). 2026:e77164. PMID: 42669156. research paper
  8. Yuan D, Li S, Zhang R, Ng RH, Su Y, Lan L, et al. A distinct effector B cell population drives autoantibody production in SARS-CoV-2 infection. Immunity. 2026. PMID: 42664960. research paper
  9. Hincapie AM, Poirier A, Aubry I, Aumont P, Bhagrath A, Uetani N, et al. Ptpn2 limits plasma cell fate and antiviral immunity by integrating B cell receptor and IFN-γ signals in B cells. Sci Adv. 2026;12:eaec0162. PMID: 42616863. research paper
  10. George-Alexander LMM, Roy R, Hicks SL, Gupta M, Scharer CD, Boss JM. Isotype-specific antibody secreting plasma cells harbor epigenetic and transcription factor architectures defining distinct cell lineages. J Immunol. 2026;215:vkag231. PMID: 42607312. research paper
  11. de Fallois J, Baatz S, Krüger BM, Dilz LM, Boldt A, Beck J, et al. Type-II-CD20-targeted therapy for CD38 antibody-refractory antibody-mediated rejection after kidney transplantation: a case report. Front Immunol. 2026;17:1867833. PMID: 42591348. research paper
  12. Cui X, Yu L, Zhang R, Huang Y, Hu Z, Li X, et al. Tea saponin-soybean oil submicron emulsion promotes durable protective immunity against Pasteurella multocida. Front Immunol. 2026;17:1899202. PMID: 42548716. research paper
  13. Nawaz W, Fong A, Cardoso MP, Tang J, Zhao J, Li MY, et al. Non-canonical NF-κB drives a fate switch from germinal center to early effector B cells. iScience. 2026;29:116917. PMID: 42540498. research paper
  14. Joshi MV, Hofland U, Morel L. Germinal center and extrafollicular dysregulation in systemic lupus erythematosus: Mechanisms and therapeutic opportunities. Autoimmun Rev. 2026;25:104146. PMID: 42503367. research paper
  15. Lin YH, Chen MH, Hsu TS, Chung WH, Lin PC, Liu PC, et al. One-carbon metabolism upregulated in lupus promotes the differentiation and effector functions of human B and T cells. Rheumatology (Oxford). 2026;65:keag381. PMID: 42490203. research paper
  16. Hirakawa R, Hisamatsu M, Maekawa S, Asai E, Ohta M, Matsuo A, et al. Bursa of Fabricius-independent B cells establish an IgA-mediated intestinal barrier that safeguards gut-liver homeostasis. Proc Natl Acad Sci U S A. 2026;123:e2605569123. PMID: 42455659. research paper
  17. Seki N, Tsujimoto H, Tanemura S, Maeda Y, Kikuchi J, Kondo Y, et al. T peripheral helper 1 cells effectively drive atypical double-negative CD11chi B cells to antibody-secreting cells and play a pathogenic role in systemic lupus erythematosus. Clin Immunol. 2026;287:110749. PMID: 42447945. research paper
  18. Cho SY, Rantalainen K, Ozorowski G, Lu D, Tingle R, Lee WH, et al. Structural basis of membrane engagement and polyreactivity control in HIV-1 MPER broadly neutralizing antibodies. Proc Natl Acad Sci U S A. 2026;123:e2609827123. PMID: 42446980. research paper
  19. Shirai T, Kuzuya K, Kishi M, Ichikawa S, Sakakibara S, Nakai A, et al. Migration-dependent extrafollicular programming of preplasmablast age-associated B cells drives lupus pathogenesis. J Clin Invest. 2026;136:e204095. PMID: 42446945. research paper
  20. Alturaiki W. BAFF as a Key Modulator of Respiratory Mucosal B Cell Immunity in Viral Infection and Mucosal Vaccination. Cells. 2026;15:1140. PMID: 42439617. research paper
  21. de Mol J, Katra P, Smit V, Witteveen A, Tomas L, Andersson L, et al. Age-associated B cells predict coronary events in humans and aggravate murine atherosclerosis. Cardiovasc Res. 2026;122:1789-1802. PMID: 42433156. research paper
  22. Arakawa Y, Taniyama D, Suzuki K, Yano S, Pommier Y. Schlafen 11 Is Overexpressed in Multiple Myeloma and Undergoes Nucleolar Translocation in Response to Bortezomib. Cancer Res Commun. 2026;6:1777-1793. PMID: 42424601. research paper
  23. Horzum U, Oberacher H, Haun M, Geley S, Roman-Trufero M, Auner H, et al. Targeting endoplasmic reticulum export disrupts metabolic resilience in multiple myeloma. Signal Transduct Target Ther. 2026;11:262. PMID: 42409778. research paper
  24. Tjønnfjord GE, Osnes LTN, Spetalen S, Haave U, Popperud TH, Maniaol AH, et al. Anti-MAG Polyneuropathy: Characterization of the Monoclonal Gammopathy and Clonal B-Cell Population. J Immunol Res. 2026;2026:e1959235. PMID: 42396941. research paper
  25. Praité A, Lambert JM, Ashi MO, Troadec E, Oblet C, Carle B, et al. Antibody-secreting Cells Integrate Efficient NMD With Non‑canonical UPR Signaling to Maintain Proteostasis and Support Massive Immunoglobulin Synthesis. J Mol Biol. 2026;438:169919. PMID: 42372940. research paper
  26. Xu W, Nwankwo I, Prigge ST, Ke H. Inheritance of four-membrane-bound structures in the "apicoplast-minus" Plasmodium falciparum. mSphere. 2026;11:e0002426. PMID: 42370693. research paper
  27. Wang Y, Ji W, Teng F, Han Y, Xu H, Zhi Y, et al. Immunological profiling of rheumatoid factor-positive primary Sjögren's syndrome by single-cell RNA sequencing. Front Immunol. 2026;17:1822615. PMID: 42367820. research paper
  28. Lu R, Swartwout BK, Oh JH, Biswas SR, van Pijkeren JP, Luo XM. Differences in the cell wall architecture drive strain-specific IgA induction by Limosilactobacillus reuteri. J Leukoc Biol. 2026;118:qiag088. PMID: 42345455. research paper
  29. Bach L, Chang Y, Arteaga Transito O, Ghasemi M, Steinheuer LM, Steffen T, et al. TGF-β and IL-2 differentially shape T follicular regulatory cell differentiation and stability in vitro. Cell Mol Immunol. 2026;23:1022-1037. PMID: 42342921. research paper
  30. Chen M, Wang W, Cheng Y, Tang Y. Molecular characterisation of telitacicept response phenotypes in systemic lupus erythematosus: an exploratory integrated transcriptome and B-cell receptor repertoire profiling study. J Transl Med. 2026;24:1113. PMID: 42316250. research paper
  31. Rødseth AV, Lundin KEA, Sollid LM, Iversen R. Celiac disease plasma cells recognize the active form of transglutaminase 2 with and without bound substrate. J Autoimmun. 2026;162:103591. PMID: 42314261. research paper
  32. Chen C, Xiao G, Yang K, Han X, Yang Y, Zhou T, et al. MZB1 Modulates Inflammatory Severity in Severe Acute Pancreatitis through an IgA-Associated Intestinal Barrier Axis. Inflammation. 2026;49:178. PMID: 42283950. research paper
  33. Sternbach N, Bishara S, Gertz MA, Vaxman I. Waldenström Macroglobulinemia Presenting With Hepatic Lesions: Case Report and Literature Review. Case Rep Hematol. 2026;2026:9908044. PMID: 42282257. research paper
  34. Ueno M, Kubo S, Todoroki Y, Nakayamada S, Tanaka Y. Immune regulation and cell metabolism in B cell subsets in patients with systemic lupus erythematosus. Front Immunol. 2026;17:1755589. PMID: 42273699. research paper
  35. Li S, Peng Y, Yang Z, Li X, Xu Z, Rivera CE, et al. B cell TET2 recruits OGT for nuclear TET2 and H2B O-GlcNAcylation to drive AID and BLIMP-1 expression and maturation of the antibody response. Cell Rep. 2026;45:117370. PMID: 42268715. research paper
  36. Harms Pritchard G, Krishnamurty AT, Rodda LB, Thouvenel CD, Bangs DJ, McDougal CE, et al. BCL6 is required for the development of functionally responsive IgM+ GC Tfh-independent memory B cells. J Exp Med. 2026;223:e20252336. PMID: 42268260. research paper
  37. Porr C, Vidrighin A, Harris DM, Diaconu C. Correlations between IgG4-related disease, autoimmune pancreatitis, and allergic diseases. Front Immunol. 2026;17:1718303. PMID: 42238580. research paper
  38. Faliti CE, Ghimire M, Garcia-Vega M, Watermeier RC, Callahan A, Burke J, et al. Defective B cell tolerance in SLE lymph nodes underpins VH4-34 "clonal damnation" and PD-1+TOX+ autoreactive B cells expansion. medRxiv. 2026. PMID: 42238417. research paper
  39. Akessé AA, Bonaud A. Not all plasma cells are made equal: well-hidden layers of heterogeneity. Front Immunol. 2026;17:1809241. PMID: 42199405. research paper
  40. Zhao J, He X, Hong P, Lin L, Du Y, Chen P, et al. RNA helicase DHX29 controls the translation of transcription factors involved in germinal center response and plasma cell differentiation in mice. EMBO J. 2026;45:4605-4635. PMID: 42192126. research paper
  41. Zachova K, Cutkova A, Kosztyu P, Ohyama Y, Takahashi K, Zadrazil J, et al. IgA nephropathy-associated breast milk B cell alterations. Front Immunol. 2026;17:1784598. PMID: 42183291. research paper
  42. Reinke JG, Schorr C, Lee KP. Why are long-lived plasma cells long-lived? Front Immunol. 2026;17:1785563. PMID: 42183219. research paper
  43. Maekawa R, Matsuoka R, Maeda Y, Fujimoto T. [A case of IgG4-related hypertrophic pachymeningitis and leptomeningitis presenting with cognitive impairment]. Rinsho Shinkeigaku. 2026;66:395-400. PMID: 42178244. research paper
  44. Xu Q, Shi L, Center for Human Immunology, Liu C, Kabat J, Behzadpour H, et al. SARS-CoV-2 infection and vaccination elicit distinct pharyngeal mucosal B cell responses in children. Nat Commun. 2026;17:6924. PMID: 42173827. research paper
  45. Tangye SG. Human CD21loT-bet+ B cells: Not as easy as "ABC"! J Hum Immun. 2026;2:e20260023. PMID: 42169684. research paper
  46. Foroutan Pajoohian P, Aradottir Pind AA, Molina Estupiñan JL, Christensen D, Pedersen GK, Olafsdottir TA, et al. Parenteral neonatal priming followed by heterologous mucosal booster favors IgM+ memory B cell induction over systemic plasma cell differentiation. Front Immunol. 2026;17:1792155. PMID: 42164486. research paper
  47. Zhao W, Zhao Y, Li H, Yang B, Lu S, Fu X, et al. SSR4 Sustains Tertiary Lymphoid Structures by Regulation Quality Control of N-linked Glycosylation During B-cell Differentiation Into Plasmacyte in Colorectal Cancer. Adv Sci (Weinh). 2026;13:e75790. PMID: 42159884. research paper
  48. Ugolkov Y, Volkova A, Helmlinger G, Peskov K, Sokolov V. Quantitative systems pharmacology model of B cell immune response in mouse. Front Immunol. 2026;17:1745710. PMID: 42148090. research paper
  49. Zhang N, Liu X, Zhu R, Dong WJ, Huang YH, Zhang YA, et al. Critical roles of CD4-1+ T cells and their secreted IL-21 in vaccine-induced humoral immunity in grass carp. Fish Shellfish Immunol. 2026;175:111421. PMID: 42119748. research paper
  50. Luff DH, Vanes L, Boeing S, Tybulewicz VLJ. TACI regulates marginal zone B cell development. J Exp Med. 2026;223:e20251308. PMID: 42085021. research paper
  51. Cho SH, Jones MA, Meyer K, Anderson DM, Chetyrkin S, Calcutt MW, et al. B cell expression of an enzymatic intermediary in ether lipid biosynthesis promotes antibody responses and germinal center size. Elife. 2026;14:RP104580. PMID: 42044181. research paper
  52. Xiang MY, Vaidehi Narayanan H, Kesarwani V, Vanheusden R, Wang T, Hoffmann A. Phased fragility and stability of non-genetic B cell states in the germinal center accelerate the genetic evolution of antibodies. Cell Syst. 2026;17:101590. PMID: 42013839. research paper
  53. Larue M, Bitoun S, Zuber J, Michel M, Talbot A. Bispecific T-cell engagers in autoimmune diseases: mechanisms of action, clinical evidence challenges, and therapeutic perspectives. Autoimmun Rev. 2026;25:104060. PMID: 42002248. research paper
  54. Wiggins KJ, Williams ME, Hicks SL, Padilla-Quirarte HO, Roman CJ, Akther J, et al. Transcriptional programming of early-forming memory B cells arises independently of cognate CD4+ T-cell interactions. J Immunol. 2026;215:vkag054. PMID: 42001515. research paper
  55. Ji X, Qing P, Lyu H, Zhang S, Wu Y, Zhuang Y, et al. UPLC-MS/MS-based metabolomics analysis identifies disease-associated metabolic signatures of B cells from patients with IgG4-RD. Front Immunol. 2026;17:1777700. PMID: 41993164. research paper
  56. Zhang H, He W. Clinicopathological and Imaging Distinction Between Ocular Adnexal MALT Lymphoma and IgG4-Related Ophthalmic Disease. Am J Ophthalmol. 2026;288:92-104. PMID: 41985855. research paper
  57. Fields CA, Bhattacharya D. Plasma cell ontogenies, functions, and lifespans. Immunity. 2026;59:833-846. PMID: 41985441. research paper
  58. Mai Z, Wei Y, Pan M, Fang G, Deng J, Huang Y, et al. B cell immune response to Talaromyces marneffei infection in HIV-negative patients and rat models. BMC Infect Dis. 2026;26:1006. PMID: 41965524. research paper
  59. Barros da Silva P, Duarte A, Almadhi NH, Alazzaz R, Borges A, Cabeçadas J, et al. Exploring the intersection: adult orbital xanthogranulomatous disease and IgG4-related disease - report of 3 cases and literature review. Orbit. 2026;45:593-602. PMID: 41949590. research paper
  60. Gao M, Yan X, Chen L, Ouyang G, Liu Y, Chen S. Morphology-based cytogenetic risk prediction in multiple myeloma from bone marrow smears. Front Oncol. 2026;16:1790130. PMID: 41930202. research paper
  61. Wang L, Curry JL, Dai J, Wang DH, Strati P, Becnel MR, et al. A Rare Case of Cutaneous Crystal-Storing Histiocytosis With Kappa Light Chain Restriction and Unusual BCL6 Expression. J Cutan Pathol. 2026;53:682-686. PMID: 41913538. research paper
  62. Wu Z, Wang C, Ma L, Xia D. Mesenchymal stem cells ameliorate Sjögren disease by suppressing B cells through the Pik3cb/Akt/mTOR pathway. Front Immunol. 2026;17:1761950. PMID: 41909663. research paper
  63. Liao C, Chen Y, Ye C, Lin S, Bai L, Zhang Z, et al. The BAFF/APRIL system at the crossroads of B cell memory and autoimmune relapse: Implication into the therapeutic strategies. Autoimmun Rev. 2026;25:104042. PMID: 41903743. research paper
  64. Goto H, Sasaki Y, Abe Y, Yagi M, Mizumoto N, Onozato Y, et al. Endoscopically-detected small-intestinal lesions with dense infiltration of IgG4-positive plasma-cells. Clin J Gastroenterol. 2026;19:550-556. PMID: 41893956. research paper
  65. Liu R, Ren T, Xu L, Wang N, Zhang Y, Yan H, et al. Single-cell atlas of B cell heterogeneity in lacrimal IgG4-related disorders: Unraveling the transition from inflammatory exhaustion to clonal malignancy. FEBS J. 2026;293:4992-5007. PMID: 41853890. research paper
  66. Padilla-Quirarte HO, Kania AK, Janto NV, Akdogan-Ozdilek B, Hicks SL, Roman CJ, et al. Heme enhances B-cell proliferation and plasma cell formation through reduced p21 and Rb expression. J Immunol. 2026;215:vkag025. PMID: 41847861. research paper
  67. Fang Z, Tian Z, Tang J, Lei B, He Z, Zhu C, et al. A case of solitary bone plasmacytoma to multiple myeloma: a case report. Front Med (Lausanne). 2026;13:1774242. PMID: 41822898. research paper
  68. Iborra-Pernichi M, de León P, Torres E, Defaus S, Blanco E, Andreu D, et al. Foot-and-mouth disease virus-derived dendrimer peptides induce germinal center-dependent antibody responses and IgG1 plasma cell differentiation in mice. Sci Rep. 2026;16:13198. PMID: 41813793. research paper
  69. Liu Y, Hu Y, Se-Rigeleng, Yang Z, Liu X, Yu J, et al. Nerandomilast attenuates idiopathic inflammatory myopathy-associated interstitial lung disease via inhibiting proliferation and differentiation of B cells. Front Immunol. 2026;17:1771007. PMID: 41789097. research paper
  70. Alapat DV, Etebari P, Van Rhee F. Elucidating the grading intricacies of idiopathic multicentric Castleman disease histopathology: a pathologist's perspective. Am J Clin Pathol. 2026;165:aqaf134. PMID: 41774910. research paper
  71. D'Souza LJ, Young JN, Coffman H, Petrow EP, Bhattacharya D. A genome-wide CRISPR screen reveals novel determinants of long-lived plasma cell secretory capacity. J Immunol. 2026;215:vkaf354. PMID: 41764730. research paper
  72. Jiang G, Yan X, Zheng Y, Zhuang L, Liu C, Zhang J, et al. Modified Shenlingbaizhu decoction suppresses colon cancer via enhancing memory-like Tfh differentiation and B cell responses. Phytomedicine. 2026;153:158001. PMID: 41763139. research paper
  73. St Clair LA, Watters EG, Yin A, Liu JA, Chaulagain S, Thompson EA, et al. Estradiol enhances influenza vaccine responses through B cell metabolic reprogramming in female mice. mBio. 2026;17:e0396525. PMID: 41744685. research paper
  74. Mohammed SS, Alkhalifah AKS, Mirza R, Okinedo SO, Inampudi RA, Bibi A, et al. Follicular helper-like γδ T cells promote plasma cell differentiation in Behçet's disease. Front Immunol. 2026;17:1763174. PMID: 41737222. research paper
  75. Nechanitzky D, Smith LK, Nechanitzky R, Jafari SM, Haight J, Bontoux C, et al. Lymphocyte-derived cholinergic circuits modulate germinal center output and B cell activation. Nat Immunol. 2026;27:854-866. PMID: 41735533. research paper
  76. Nakada T, Saito R, Ishigaki S, Takei H, Yoshimoto K, Akiyama M, et al. Integrating B Cell Differentiation Model With Real-World Data Informs Determinants for Antibody-Secreting Cell Depletions in Systemic Sclerosis. CPT Pharmacometrics Syst Pharmacol. 2026;15:e70221. PMID: 41731244. research paper
  77. Pioli KT, Pioli PD. The evolution of antibody-secreting cell biological exploration: one mouse model at a time. Front Immunol. 2026;17:1739007. PMID: 41727469. research paper
  78. Raschdorf A, de Almeida LN, Solbach P, Kirstein MM, Marquardt JU, Schmelter F, et al. Colonic spatial single-cell proteomics and murine models link mitochondrial dysfunction to dimeric IgA-secreting plasma cell deficiency in Crohn's disease. Nat Commun. 2026;17:1590. PMID: 41680132. research paper
  79. Duntas LH. The caprices of a trace element: selenium's considerable effects on Hashimoto's thyroiditis, though few on Graves' disease. Eur Thyroid J. 2026;15:ETJ260009. PMID: 41677203. research paper
  80. Sargen M, Sasaki A, Tiwari RK, Li XM. B cell development and longevity of IgE plasma cells. Allergol Int. 2026;75:380-387. PMID: 41672834. research paper
  81. Hu X, Li D, Hu X, Li S, Wang P. Solitary plasmacytoma of the tibia: literature review and case report. Front Oncol. 2026;16:1503479. PMID: 41646436. research paper
  82. Li X, Zhang Y, Ji D, Li L, Deng Y, Wang H, et al. Multi-omics identifies an epithelial-B cell cross-talk that drives functional B cell diversion in breast cancer lymph node metastasis. Cell Signal. 2026;141:112394. PMID: 41610965. research paper
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